Polio is a highly infectious viral disease that mainly affects children under five. About one infection in 200 leads to irreversible paralysis, and 5–10% of those paralysed die when their breathing muscles stop working. Since the global eradication effort began in 1988, cases of wild poliovirus have fallen by more than 99%, from an estimated 350,000 a year in over 125 countries. WHO credits vaccination with more than 20 million people who can walk today and about 1.5 million childhood deaths prevented. Wild poliovirus type 1 is now endemic only in Afghanistan and Pakistan, which together reported 52 cases in 2025 and 747 positive sewage samples, two of them found in Germany.
The final stretch is the hardest. In parts of both endemic countries, insecurity and access limits leave children unvaccinated: in southern Khyber Pakhtunkhwa in Pakistan an estimated 250,000 children were reported unreached in recent campaigns, and Afghanistan has not run house-to-house campaigns since October 2024. At the same time, where too few children are immunised, the weakened virus in oral polio vaccine can circulate for long periods and regain the ability to paralyse. These circulating vaccine-derived outbreaks caused 238 cases in 30 countries in 2025. As long as any child remains infected, children everywhere are at risk, and WHO continues to treat the international spread of poliovirus as a public health emergency of international concern. The programme reports a funding shortfall of nearly 30%.
How polio and progress towards eradication are measured
The Global Polio Eradication Initiative (GPEI), a partnership that includes WHO, tracks the virus through laboratory-confirmed cases and sewage testing, and judges protection by vaccination coverage:
Wild poliovirus cases (WPV1)
Children with sudden paralysis are tested, and cases are counted when wild poliovirus type 1 is confirmed in a laboratory. Because only about one infection in 200 causes paralysis, each case signals many more silent infections.
Circulating vaccine-derived poliovirus (cVDPV)
Cases and outbreaks caused by strains that originated from the weakened virus in oral polio vaccine and spread in under-immunised communities. They are counted by type (1, 2 or 3) and by new 'emergences', independent outbreaks that each arose separately.
Environmental surveillance
Regular testing of sewage samples detects poliovirus even when no one is paralysed. Positive samples show where the virus is still circulating, including in countries with no cases.
Vaccination coverage
The share of infants who receive three doses of polio vaccine (Pol3) and the doses of inactivated polio vaccine (IPV) given by injection, estimated each year by WHO and UNICEF. Campaign quality is checked separately with surveys of children after vaccination rounds.